tag:blogger.com,1999:blog-731855265219120303.post5791164327305125920..comments2023-11-03T07:52:51.571-04:00Comments on Secundum Artem: Generics and Allergies ReduxN.B.http://www.blogger.com/profile/01098950427329538284noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-731855265219120303.post-75302534726107309312008-10-08T15:54:00.000-04:002008-10-08T15:54:00.000-04:00Most people start with Coumadin 5mg tablets and ad...Most people start with Coumadin 5mg tablets and adjust from there. Let's analyze the excipients for giggles.<BR/><BR/>Coumadin 5mg (Bristol): FD&C Yellow No. 6, Lactose, Magnesium Silicate, Magnesium Stearate, starch.<BR/><BR/>Coumadin 5mg (NuCare): FD&C Yellow No. 6, Lactose.<BR/><BR/>Jantoven 5mg (Upsher): FD&C Yellow No. 6, Lactose, Magnesium Stearate, Povidone, Pregelatinized Corn Starch.<BR/><BR/>Warfarin 5mg (Barr): FD&C Yellow No. 6, Lactose, Hypromellose, Magnesium Stearate, Pregelatinized Starch.<BR/><BR/>Warfarin 5mg (PD-RX): Corn Starch, D&C Red No. 6, D&C Yellow No. 10, Lactose, Magnesium Stearate. NOTE: TARO Brand uses same excipients as PD-RX.<BR/><BR/>There are some others, but Barr is the biggest -- and what's used pretty universally (at least everywhere I've ever worked). I'm betting Taro would be second most used generic.<BR/><BR/>Anyway -- what's the big fucking deal here? I can understand dyes. That's rare, and those people aren't wishy-washy. "Well, I dunno, my doctor said this. I could be allergic." <BR/><BR/>People with Dye Allergies know, because they spent years figuring it out. "Here's a prescription for X product. I am allergic to FD&C Red No.3, Blue No. 9, and codeine. They all cause X symptom."<BR/><BR/>Anyone else is full of shit.TheAngriestPharmacisthttps://www.blogger.com/profile/06205648352615791938noreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-7772368631407475032008-10-06T23:46:00.000-04:002008-10-06T23:46:00.000-04:00This has always intrigued me.My background is psyc...This has always intrigued me.<BR/><BR/>My background is psychology, but my parents were both pharmacists, so I consider myself to know more than, say, 95% of the population about drug safety, usage, effects, etc. <BR/><BR/>I then had a very intense rapid learning thrust upon me by being the information/research/advice officer for a disability-sector brain injury organisation. <BR/><BR/>During which I had long-term contact with the wife of one man who had severe behavioural issues triggered by elevated body heat from dysautonomia: In fact, the treatment when his mood could be caught early was to stand by the sink and pour cold water over his head. <BR/><BR/>And then one day the pharmacist in town (an hour's drive away) dispensed him a generic instead of his usual anti-epileptic, and he had "a reaction" and his wife had to call the police for her own protection.<BR/><BR/>The only thing I can think of is that the stress of not getting the medication he relied upon to keep him stable was the trigger, not the medication itself.Jonathan Hepburnhttps://www.blogger.com/profile/04333749909468762319noreply@blogger.com