tag:blogger.com,1999:blog-731855265219120303.post8069170699845995141..comments2023-11-03T07:52:51.571-04:00Comments on Secundum Artem: The Great Generic "Controversy"N.B.http://www.blogger.com/profile/01098950427329538284noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-731855265219120303.post-8140077278927160842010-10-13T02:18:10.526-04:002010-10-13T02:18:10.526-04:00I am all for generic drug use as it is identical t...I am all for generic drug use as it is identical to branded drugs in terms of dose, strength, safety, and efficacy. All drug manufacturers should be encouraged to apply <a href="http://www.foss-nirsystems.com/pharmaceuticals.html" rel="nofollow">near infrared spectroscopy</a> in their manufacturing process to ensure the quality of the drugs. As a matter of fact, the <a href="http://www.foss-nirsystems.com/pharmaceuticals.html" rel="nofollow">near infrared</a> technology has proven its capabilities as it is utilized in the quality control process of many industries.Georgehttps://www.blogger.com/profile/06448215506097796993noreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-59700436118975716162009-04-01T16:24:00.000-04:002009-04-01T16:24:00.000-04:00classic.medical opinion proffered by a nonclinicia...classic.medical opinion proffered by a nonclinician.your "faith"in generic drug makers (and the FDA) is simple,at best.your dogmatic attachment to bioavailability "stats" in proving[sic] your "opinion" betrays your inability to assess clinical impact on real patients.stick to filling scripts,I'll keep seeing patients.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-65630648454792817542008-03-28T16:54:00.000-04:002008-03-28T16:54:00.000-04:00Has anybody had a negative experience with generic...Has anybody had a negative experience with generic drugs? I’m looking to speak with a Minnesota patient who has been switched from a brand name drug to a generic and who could share their experience. If you are interested, please email me at mdepoint@tunheim.com.Big Bluehttps://www.blogger.com/profile/11791980028909498208noreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-60117692426484659282008-03-21T16:36:00.000-04:002008-03-21T16:36:00.000-04:00Great post! I wish more of my patients were compu...Great post! I wish more of my patients were computer-literate.<BR/><BR/>Generics have been such a boon for medication compliance.<BR/><BR/>If a patient needs, say, metoprolol for their heart, and says he can't afford it, I can remind him that it's only 4 bucks a month. That's less than one pack of cigs.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-12751773202431454952008-03-20T12:00:00.000-04:002008-03-20T12:00:00.000-04:00I'm afraid that I have not heard the specific phen...I'm afraid that I have not heard the specific phenytoin anecdote to which you refer. I'll have to look into that!N.B.https://www.blogger.com/profile/01098950427329538284noreply@blogger.comtag:blogger.com,1999:blog-731855265219120303.post-49196224478620718442008-03-19T14:38:00.000-04:002008-03-19T14:38:00.000-04:00Very well stated, N.B. I neglected to mention in ...Very well stated, N.B. I neglected to mention in my post that the potential for differences in generic bioavailability are not often of clinical significance. Where they are most relevant are, as you state, for drugs with a narrow therapeutic index or for sustained release dosage forms meant to treat chronic illnesses like depression or hypertension.<BR/><BR/>You are closer to Rx school than I but I recall a classic case in pharmaceutics that led to rules being established for dosage form changes even within the same brand name long before generics were available - I believe it was a change in excipient for phenytoin that led to an increase in bioavailability and increased incidence of gingival hyperplasia. I'm having trouble finding the original report - did they teach you about this?Anonymousnoreply@blogger.com